Exosome Evidence Index

Studies / Healing after procedures and wounds

Donor platelet vesicles injected into small skin wounds

Johnson J et al., Journal of Extracellular Vesicles, 2023

No benefit over controlStrength of design, level 3 of 5: Controlled trial

No benefit over control: The treated group did no better than placebo or the comparison.

Level 3 of 5: Treated patients were compared with a control: placebo, another treatment, or the untreated side of the face. Most exosome trials at this level are small and short.

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Design
Phase 1, randomized, double-blind, placebo-controlled
People
11 healthy volunteers
Made from
Donor platelets
How it was given
Injected into a skin biopsy wound

What they found

Safe and well tolerated. Wounds healed in about 23 days on average whether they got the vesicles or placebo.

What limits it

Healthy volunteers heal normally, so this trial could not test chronic or slow-healing wounds. Safety was its main goal.

Read the study

Reviewed by Tomaz Mesar, MD. Last reviewed October 2026. No exosome product is FDA-approved for any use. Before you book a treatment

Other studies of healing after procedures and wounds

  1. Better than controlStrength of design, level 3 of 5: Controlled trial

    The patient's own serum vesicles for chronic venous leg ulcers

    Gibello L et al., Pharmacological Research, 2023. About 5 patients. Made from: patient's own blood serum.

    Treated ulcers formed more healthy granulation tissue than sham-treated ulcers: 3 of 5 treated ulcers reached 75–100% granulation, compared with none of the sham-treated ones.

  2. Improvement reported, no control groupStrength of design, level 1 of 5: Single case or case series

    Placental exosomes on the skin for healing after aesthetic procedures

    Peredo M, Shivananjappa S, Journal of Drugs in Dermatology, 2024. 3 people. Made from: placenta.

    The authors reported faster recovery, with less redness, swelling, and pain, in all three cases.