Studies / Healing after procedures and wounds
The patient's own serum vesicles for chronic venous leg ulcers
Gibello L et al., Pharmacological Research, 2023
Better than control: The treated group did better than the comparison group on the main measures.
Level 3 of 5: Treated patients were compared with a control: placebo, another treatment, or the untreated side of the face. Most exosome trials at this level are small and short.
See the full key- Design
- Pilot case-control; one ulcer treated, another on the same leg sham-treated
- People
- About 5 patients
- Made from
- Patient's own blood serum
- How it was given
- Applied to the ulcer three times a week for 2 weeks
What they found
Treated ulcers formed more healthy granulation tissue than sham-treated ulcers: 3 of 5 treated ulcers reached 75–100% granulation, compared with none of the sham-treated ones.
What limits it
Very small, single-center, and not described as randomized. Vesicles came from each patient's own blood, and only patients whose vesicles passed a lab potency test were eligible.
Other studies of healing after procedures and wounds
- No benefit over control
Donor platelet vesicles injected into small skin wounds
Johnson J et al., Journal of Extracellular Vesicles, 2023. 11 healthy volunteers. Made from: donor platelets.
Safe and well tolerated. Wounds healed in about 23 days on average whether they got the vesicles or placebo.
- Improvement reported, no control group
Placental exosomes on the skin for healing after aesthetic procedures
Peredo M, Shivananjappa S, Journal of Drugs in Dermatology, 2024. 3 people. Made from: placenta.
The authors reported faster recovery, with less redness, swelling, and pain, in all three cases.