Studies / Dry eye from graft-versus-host disease
Umbilical cord stem cell exosome eye drops for dry eye from graft-versus-host disease
Zhou T et al., Science Advances, 2022
Improvement reported, no control group
Improvement reported, no control group: Patients improved, but without a comparison group there is no way to tell whether the treatment caused it.
Level 2 of 5: A group was treated and followed, but nobody was left untreated for comparison. Improvement may come from time, other care, or the placebo effect.
See the full key- Design
- Prospective study, no control group
- People
- 28 eyes
- Made from
- Umbilical cord
- How it was given
- Eye drops
What they found
In patients whose dry eye had not responded to other treatment, staining of the eye surface fell, tear film lasted longer, tear production rose, and symptom scores improved.
What limits it
No comparison group. Most of the paper is lab and mouse work; the human study is small.