Adipose stem cell exosome solution plus microneedling for facial aging
Park GH et al., Journal of Cosmetic Dermatology, 2023
Better than control: The treated group did better than the comparison group on the main measures.
Level 3 of 5: Treated patients were compared with a control: placebo, another treatment, or the untreated side of the face. Most exosome trials at this level are small and short.
See the full key- Design
- Randomized split-face, saline on the other side
- People
- 28 people
- Made from
- Fat (adipose) stem cells
- How it was given
- On the skin after microneedling
What they found
Wrinkle measures improved 12–14% on the exosome side and about 7% on the saline side. Elasticity rose 11.3% on the exosome side and fell 3.3% on the saline side.
What limits it
Small and short, with 12 weeks of follow-up. A 2025 systematic review rated its risk of bias as having some concerns.
Other studies of skin aging
- Similar to comparison treatment
Human and rose stem cell exosome blend compared with PRP after radiofrequency microneedling
Investigator-blinded split-face trial, 2025 (PMC12104007). 15 people (from the investigators' conference abstract). Made from: human fat stem cells and rose stem cells.
Skin biopsies looked similar on both sides, and investigators rated the exosome side slightly better, according to the investigators' conference abstract.