Adipose stem cell exosomes plus fractional CO₂ laser for acne scars
Kwon HH et al., Acta Dermato-Venereologica, 2020
Better than control: The treated group did better than the comparison group on the main measures.
Level 3 of 5: Treated patients were compared with a control: placebo, another treatment, or the untreated side of the face. Most exosome trials at this level are small and short.
See the full key- Design
- Randomized, double-blind, split-face
- People
- 25 people
- Made from
- Fat (adipose) stem cells
- How it was given
- Gel on the skin after laser
What they found
Scar severity fell 32.5% on the exosome side and 19.9% on the control side. More exosome-treated sides improved by at least two grades (16 of 25 vs 12 of 25), and redness after laser was milder.
What limits it
One small trial with 12 weeks of follow-up. Both sides had laser, so it tests exosomes as an add-on, not on their own.
Other studies of acne scars
- Improvement reported, no control group
Umbilical cord exosomes with subcision for severe acne scars
Pastrana-López S, Journal of Stem Cell Research, 2024. 1 person. Made from: umbilical cord.
The patient's acne scar score fell from 180 to 90 points.