Exosome Evidence Index

Studies / Hyperpigmentation

Adipose stem cell exosome gel for skin brightening

Cho BS et al., Cosmetics, 2020

Mixed or short-lived resultStrength of design, level 3 of 5: Controlled trial

Mixed or short-lived result: Some benefit, but only on some measures, in a subgroup, or for a short time.

Level 3 of 5: Treated patients were compared with a control: placebo, another treatment, or the untreated side of the face. Most exosome trials at this level are small and short.

See the full key
Design
Randomized, double-blind, split-face, placebo-controlled
People
21 women
Made from
Fat (adipose) stem cells
How it was given
Gel on the skin twice a day

What they found

Melanin levels dropped more on the exosome side than on the placebo side, with the largest difference at 4 weeks.

What limits it

The effect had faded by week 8. The dose applied to the skin was not reported.

Read the study