Placental stem cell vesicles injected into the knee for osteoarthritis
Bolandnazar NS et al., BMC Musculoskeletal Disorders, 2024
No benefit over control
No benefit over control: The treated group did no better than placebo or the comparison.
Level 3 of 5: Treated patients were compared with a control: placebo, another treatment, or the untreated side of the face. Most exosome trials at this level are small and short.
See the full key- Design
- Randomized, triple-blind, saline in the other knee
- People
- 31 people (62 knees)
- Made from
- Placenta
- How it was given
- One injection into the knee
What they found
No difference from saline in pain, function, or MRI findings at 2 and 6 months. The injection was safe.
What limits it
A small trial testing a single injection.
Other studies of knee osteoarthritis
- Safety only
First human knee injection of a clinical-grade umbilical cord vesicle product
Figueroa-Valdés AI et al., Journal of Nanobiotechnology, 2025. 1 person. Made from: umbilical cord.
No adverse effects over 12 months of follow-up.